human PON3 Over-expression AAV

Name 
AAV-h-PON3
Cat No 
AAV-219445
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human PON3.

AAV-219445
AAV-h-PON3

Ready-to-use AAV expressing Human PON3 (paraoxonase 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Description (Vector)
PON3 is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized.
Gene ID
5446
Gene Name (Vector)
paraoxonase 3
Gene Symbol
PON3
HGNC ID
HGNC:9206
ORF Size (aa)
1065
ORF Size (bp)
1065 bp
RefSeq ID
NM_000940
RefSeq Synonyms
NM_000940, BC070374,
Species
human
UniGene ID
Hs.440967

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.