human POLR3E Over-expression AAV

Name 
AAV-h-POLR3E
Cat No 
AAV-219418
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human POLR3E.

AAV-219418
AAV-h-POLR3E

Ready-to-use AAV expressing Human POLR3E (RNA polymerase III subunit E). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
DNA-directed RNA polymerase III 80 kDa polypeptide; DNA-directed RNA polymerase III subunit RPC5; polymerase (RNA) III (DNA directed) polypeptide E (80kD); polymerase (RNA) III subunit E; RNA polymerase III 80 kDa subunit RPC5; RNA polymerase III subunit C5; RPC5; SIN
Description (eCommerce)
POLR3E (RNA polymerase III polypeptide E 80kDa) is a DNA-dependent RNA polymerase that catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. POLR3E is a specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. It is essential for efficient transcription from both the type 2 VAI and type 3 U6 RNA polymerase III promoters. POLR3E plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q9NVU0].
Gene ID
55718
Gene Name (eCommerce)
RNA polymerase III subunit E
Gene Name (Vector)
RNA polymerase III subunit E
Gene Symbol
POLR3E
HGNC ID
HGNC:30347
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2001
ORF Size (bp)
2001 bp
Protein Name (eCommerce)
DNA-directed RNA polymerase III subunit RPC5
RefSeq ID
NM_018119
RefSeq Synonyms
NM_018119, NM_001258036, NM_001258035, NM_001258034, NM_001258033, BC000285,
Research Areas
Gene Expression,Host-Virus Interactions,Immunology,Innate Immunity,Response to Virus,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,immunology,infectious_disease,transcription_translation
Species
human
Target Sentence
POLR3E (RNA polymerase III polypeptide E 80kDa) is a DNA-dependent RNA polymerase that catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. POLR3E is a specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. It is essential for efficient transcription from both the type 2 VAI and type 3 U6 RNA polymerase III promoters. POLR3E plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q9NVU0].
UniGene ID
Hs.460298
UniProt ID (eCommerce)
Q9NVU0

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.