human POLI Over-expression AAV

Name 
AAV-h-POLI
Cat No 
AAV-219368
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human POLI.

AAV-219368
AAV-h-POLI

Ready-to-use AAV expressing Human POLI (DNA polymerase iota). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
DNA polymerase iota; eta2; polymerase (DNA directed) iota; polymerase (DNA) iota; polymerase (DNA-directed), iota; RAD30 homolog B; RAD30B; RAD3OB
Description (eCommerce)
Pol Iota is a DNA polymerase involved in DNA repair and translesion DNA synthesis. Pol Iota is a member of the Rad30 family of DNA polymerases which exhibit low fidelity when replicating undamaged DNA, and in this context may play a role in the hypermutation of immunoglobulin genes. Pol Iota is also known as RAD30B and is a paralog of RAD30A, also known as Pol eta.
Gene ID
11201
Gene Name (eCommerce)
DNA polymerase iota
Gene Name (Vector)
DNA polymerase iota
Gene Symbol
POLI
HGNC ID
HGNC:9182
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2148
ORF Size (bp)
2148 bp
Protein Name (eCommerce)
DNA polymerase iota
RefSeq ID
NM_007195
RefSeq Synonyms
NM_007195, BC032662,
Research Areas
DNA Damage/Repair,DNA Replication,Fanconi anemia
Research Areas (Faceted)
genetics,transcription_translation,cell_biology
Species
human
Target Sentence
Pol Iota is a DNA polymerase involved in DNA repair and translesion DNA synthesis. Pol Iota is a member of the Rad30 family of DNA polymerases which exhibit low fidelity when replicating undamaged DNA, and in this context may play a role in the hypermutation of immunoglobulin genes. Pol Iota is also known as RAD30B and is a paralog of RAD30A, also known as Pol eta.
UniGene ID
Hs.438533
UniProt ID (eCommerce)
Q9UNA4

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.