human PNN Over-expression AAV

Name 
AAV-h-PNN
Cat No 
AAV-219307
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human PNN.

AAV-219307
AAV-h-PNN

Ready-to-use AAV expressing Human PNN (pinin, desmosome associated protein). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
140 kDa nuclear and cell adhesion-related phosphoprotein; desmosome-associated protein; domain-rich serine protein; DRS; DRS protein; DRSP; melanoma metastasis clone A protein; memA; neutrophil protein; nuclear protein SDK3; pinin; SDK3; SR-like protein
Description (eCommerce)
PNN is a nuclear and cell adhesion-related protein involved in cell adhesion, mRNA processing, and transcriptional regulation. PNN functions as a transcriptional regulator by relieving CtBP1-mediated repression of the E-cadherin gene. In the role of mRNA processing, PNN functions as a splicing regulator. The role of PNN in transcription and mRNA processing suggests the role of PNN as a coupling factor for the two processes.
Gene ID
5411
Gene Name (eCommerce)
pinin, desmosome associated protein
Gene Name (Vector)
pinin, desmosome associated protein
Gene Symbol
PNN
HGNC ID
HGNC:9162
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2154
ORF Size (bp)
2154 bp
Protein Name (eCommerce)
Pinin
RefSeq ID
NM_002687
RefSeq Synonyms
NM_002687, BC062602,
Research Areas
Cancer,Cell Cycle,Gene Expression,mRNA Processing,mRNA Splicing,RNA Processing,RNA Transport,Spliceosome,Transcription Factor/Regulator,Tumor Suppressors/Oncoproteins
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,genetics,transcription_translation,cell_biology,genetics,cancer
Species
human
Target Sentence
PNN is a nuclear and cell adhesion-related protein involved in cell adhesion, mRNA processing, and transcriptional regulation. PNN functions as a transcriptional regulator by relieving CtBP1-mediated repression of the E-cadherin gene. In the role of mRNA processing, PNN functions as a splicing regulator. The role of PNN in transcription and mRNA processing suggests the role of PNN as a coupling factor for the two processes.
UniGene ID
Hs.409965
UniProt ID (eCommerce)
Q9H307

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AAV-h-PNMT

Cat No: AAV-219306

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.