human PKD2 Over-expression AAV

Name 
AAV-h-PKD2
Cat No 
AAV-219022
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human PKD2.

AAV-219022
AAV-h-PKD2

Ready-to-use AAV expressing Human PKD2 (polycystin 2, transient receptor potential cation channel). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
APKD2; autosomal dominant polycystic kidney disease type II protein; PC2; Pc-2; PKD4; polycystic kidney disease 2 (autosomal dominant); Polycystic kidney disease 2 protein; polycystin-2; Polycystwin; R48321; transient receptor potential cation channel subfamily P member 2; TRPP2
Description (eCommerce)
Polycystin-2 is a calcium permeable cation channel. Defects in the Polycystin-2 gene, PKD2, are the cause of polycystic kidney disease autosomal dominant type 2 (ADPKD2) which is characterized by progressive formation and enlargement of cysts in both kidneys, typically leading to end-stage renal disease in adult life. Cysts also occur in the liver and other organs [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q13563].
Description (Vector)
PKD2 encodes a member of the polycystin protein family. The encoded protein is a multi-pass membrane protein that functions as a calcium permeable cation channel, and is involved in calcium transport and calcium signaling in renal epithelial cells. This protein interacts with polycystin 1, and they may be partners in a common signaling cascade involved in tubular morphogenesis. Mutations in this gene are associated with autosomal dominant polycystic kidney disease type 2.
Gene ID
5311
Gene Name (eCommerce)
polycystin 2, transient receptor potential cation channel
Gene Name (Vector)
polycystin 2, transient receptor potential cation channel
Gene Symbol
PKD2
HGNC ID
HGNC:9009
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2907
ORF Size (bp)
2907 bp
Protein Name (eCommerce)
Polycystin-2
RefSeq ID
NM_000297
RefSeq Synonyms
NM_000297, BC112263, BC112261, BC111454,
Research Areas
Cancer,Cardiac Development,Cardiology,Cardiovascular,Cell Cycle,Cytoskeleton,JAK-STAT Signaling,Neurobiology,Neurodevelopment,Signal Transduction,Transport
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,cell_cycle,developmental_biology,genetics,neurobiology,signal_transduction
Species
human
Target Sentence
Polycystin-2 is a calcium permeable cation channel. Defects in the Polycystin-2 gene, PKD2, are the cause of polycystic kidney disease autosomal dominant type 2 (ADPKD2) which is characterized by progressive formation and enlargement of cysts in both kidneys, typically leading to end-stage renal disease in adult life. Cysts also occur in the liver and other organs [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q13563].
UniGene ID
Hs.181272
UniProt ID (eCommerce)
Q13563

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.