human PILRA Over-expression AAV
This is an AAV expressing Human PILRA.
AAV-218967
AAV-h-PILRA
Ready-to-use AAV expressing Human PILRA (paired immunoglobin like type 2 receptor alpha). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
FDF03
Description (Vector)
Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described.
Gene ID
29992
Gene Name (Vector)
paired immunoglobin like type 2 receptor alpha
Gene Symbol
PILRA
HGNC ID
HGNC:20396
ORF Size (aa)
681
ORF Size (bp)
681 bp
RefSeq ID
NM_013439
RefSeq Synonyms
NM_178273, NM_178272, NM_013439, BC017812,
Species
human
UniGene ID
Hs.444407
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.