human PDZD3 Over-expression AAV

Name 
AAV-h-PDZD3
Cat No 
AAV-218573
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human PDZD3.

AAV-218573
AAV-h-PDZD3

Ready-to-use AAV expressing Human PDZD3 (PDZ domain containing 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
IKEPP; NHERF4; PDZK2
Description (Vector)
Guanylyl cyclase C (GCC, or GUCY2C; MIM 601330) produces cGMP following the binding of either endogenous ligands or heat-stable enterotoxins secreted by E. coli and other enteric bacteria. Activation of GCC initiates a signaling cascade that leads to phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR; MIM 602421), followed by a net efflux of ions and water into the intestinal lumen. IKEPP is a regulatory protein that associates with GCC and regulates the amount of cGMP produced following receptor stimulation (Scott et al., 2002 (PubMed 11950846)).(supplied by OMIM, Mar 2008)
Gene ID
79849
Gene Name (Vector)
PDZ domain containing 3
Gene Symbol
PDZD3
HGNC ID
HGNC:19891
ORF Size (aa)
1476
ORF Size (bp)
1476 bp
RefSeq ID
NM_024791
RefSeq Synonyms
NM_024791, NM_001168468, BC029042,
Species
human
UniGene ID
Hs.374726

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.