human PCSK1 Over-expression AAV

Name
AAV-h-PCSK1

Cat No
AAV-218407

Availability
4-5 weeks

This is an AAV expressing Human PCSK1.

AAV-218407

AAV-h-PCSK1

Ready-to-use AAV expressing Human PCSK1 (proprotein convertase subtilisin/kexin type 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

BMIQ12; NEC1; PC1; PC3; SPC3;

Description (Vector)

PCSK1 belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a type I proinsulin-processing enzyme that plays a key role in regulating insulin biosynthesis. It is also known to cleave proopiomelanocortin, prorenin, proenkephalin, prodynorphin, prosomatostatin and progastrin. Mutations in this gene are thought to cause obesity. This encoded protein is associated with carcinoid tumors. Mutations in this gene have been associated with susceptibility to obesity and proprotein convertase 1/3 deficiency. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene ID

5122

Gene Name (Vector)

proprotein convertase subtilisin/kexin type 1

Gene Symbol

PCSK1

HGNC ID

HGNC:8743

ORF Size (aa)

2262

ORF Size (bp)

2262 bp

RefSeq ID

NM_000439

RefSeq Synonyms

NM_001177876, NM_001177875, NM_000439, BC136486, BC130295,

Species

human

UniGene ID

Hs.78977

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.