human PAK1 Over-expression AAV
This is an AAV expressing Human PAK1.
AAV-218151
AAV-h-PAK1
Ready-to-use AAV expressing Human PAK1 (p21 (RAC1) activated kinase 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
alpha-PAK; p21 protein (Cdc42/Rac)-activated kinase 1; p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast); p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related); p21-activated kinase 1; p65-PAK; PAK-1; PAKalpha; serine/threonine-protein kinase PAK 1; STE20 homolog, yeast
Description (eCommerce)
PAK1 (p21-activated kinase 1) is part of the family of PAK serine/threonine p21-activating protein kinases involved in cell survival, migration, and invasion. PAK1 mediates signals from extracellular stimuli to the cytoplasm and nucleus via its association with the small GTP-binding proteins, Cdc42 and Rac. GTPase binding to PAK1 activates PAK1 kinase activity and leads to reorganization of the actin cytoskeleton and the phosphorylation of proteins involved in survival, energy metabolism, gene expression, cell motility, cell morphology, and the cell cycle.
Description (Vector)
PAK1 encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene ID
5058
Gene Name (eCommerce)
p21 (RAC1) activated kinase 1
Gene Name (Vector)
p21 (RAC1) activated kinase 1
Gene Symbol
PAK1
HGNC ID
HGNC:8590
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1638
ORF Size (bp)
1638 bp
Protein Name (eCommerce)
Serine/threonine-protein kinase PAK 1
RefSeq ID
NM_002576
RefSeq Synonyms
NM_002576, NM_001128620, BC109299,
Research Areas
Angiogenesis,Apoptosis,Axon Guidance,Breast Cancer,Cancer,Cardiovascular,CD95/FAS Signaling,Cell Cycle,Cytoskeleton,EGFR Signaling,EPO Signaling,Estrogen Signaling,Fc Receptor Signaling,Gene Expression,Golgi Apparatus,HGF Signaling,Hypoxia,Immunology,Innate Immunity,Interleukin Signaling,JAK-STAT Signaling,JNK Signaling,Kidney Cancer,Kinase/Phosphatase,Lung Cancer,MAPK Signaling,Neurobiology,Neurodevelopment,PDGF Signaling,PLK1 Signaling,Prolactin Signaling,Prostate Cancer,RAC1 Signaling,Signal Transduction,T-cell Receptor Signaling,TNF Signaling,VEGF Signaling
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,cell_cycle,developmental_biology,genetics,immunology,neurobiology,signal_transduction
Species
human
Target Sentence
PAK1 (p21-activated kinase 1) is part of the family of PAK serine/threonine p21-activating protein kinases involved in cell survival, migration, and invasion. PAK1 mediates signals from extracellular stimuli to the cytoplasm and nucleus via its association with the small GTP-binding proteins, Cdc42 and Rac. GTPase binding to PAK1 activates PAK1 kinase activity and leads to reorganization of the actin cytoskeleton and the phosphorylation of proteins involved in survival, energy metabolism, gene expression, cell motility, cell morphology, and the cell cycle.
UniGene ID
Hs.435714
UniProt ID (eCommerce)
Q13153
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.