human PACS1 Over-expression AAV

Name
AAV-h-PACS1

Cat No
AAV-218104

Availability
4-5 weeks

This is an AAV expressing Human PACS1.

AAV-218104

AAV-h-PACS1

Ready-to-use AAV expressing Human PACS1 (phosphofurin acidic cluster sorting protein 1). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

MRD17; SHMS

Description (Vector)

PACS1 encodes a protein with a putative role in the localization of trans-Golgi network (TGN) membrane proteins. Mouse and rat homologs have been identified and studies of the homologous rat protein indicate a role in directing TGN localization of furin by binding to the protease's phosphorylated cytosolic domain. In addition, the human protein plays a role in HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the TGN, thereby enabling HIV-1 to escape immune surveillance.

Gene ID

55690

Gene Name (Vector)

phosphofurin acidic cluster sorting protein 1

Gene Symbol

PACS1

HGNC ID

HGNC:30032

ORF Size (aa)

2892

ORF Size (bp)

2892 bp

RefSeq ID

NM_018026

RefSeq Synonyms

NM_018026, BC052577, BC010096,

Species

human

UniGene ID

Hs.644326

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.