human OXSR1 Over-expression AAV

Name 
AAV-h-OXSR1
Cat No 
AAV-218031
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human OXSR1.

AAV-218031
AAV-h-OXSR1

Ready-to-use AAV expressing Human OXSR1 (oxidative stress responsive 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
OSR1; oxidative stress-responsive 1 protein; serine/threonine-protein kinase OSR1
Description (eCommerce)
Oxidative stress responsive 1 (OSR1) is a STE20-related kinase involved in ion transport and fluid and ion homeostasis. OSR1 interacts with SPAK (STE20/SPS1-reated proline/alanine-rich kinase) and together are activated by the upstream kinase WNK1 [with no K (lysine) protein kinase-1]. Activation of OSR1 and SPAK by WNK1 results in the phosphorylation and activation of NKCC1 (Na+-K+-2Cl- co-transporter 1) for the control of cell volume and blood pressure.
Description (Vector)
The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton.
Gene ID
9943
Gene Name (eCommerce)
oxidative stress responsive 1
Gene Name (Vector)
oxidative stress responsive 1
Gene Symbol
OXSR1
HGNC ID
HGNC:8508
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1584
ORF Size (bp)
1584 bp
Protein Name (eCommerce)
Serine/threonine-protein kinase OSR1
RefSeq ID
NM_005109
RefSeq Synonyms
NM_005109, BC008726,
Research Areas
Kinase/Phosphatase,Neurobiology,Signal Transduction
Research Areas (Faceted)
signal_transduction,cell_biology,neurobiology
Species
human
Target Sentence
Oxidative stress responsive 1 (OSR1) is a STE20-related kinase involved in ion transport and fluid and ion homeostasis. OSR1 interacts with SPAK (STE20/SPS1-reated proline/alanine-rich kinase) and together are activated by the upstream kinase WNK1 [with no K (lysine) protein kinase-1]. Activation of OSR1 and SPAK by WNK1 results in the phosphorylation and activation of NKCC1 (Na+-K+-2Cl- co-transporter 1) for the control of cell volume and blood pressure.
UniGene ID
Hs.475970
UniProt ID (eCommerce)
O95747

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.