human OXCT1 Over-expression AAV

Name 
AAV-h-OXCT1
Cat No 
AAV-218022
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human OXCT1.

AAV-218022
AAV-h-OXCT1

Ready-to-use AAV expressing Human OXCT1 (3-oxoacid CoA-transferase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
3-oxoacid CoA transferase; 3-oxoacid CoA-transferase 1; epididymis secretory sperm binding protein; OXCT; SCOT; SCOT-s; somatic-type succinyl-CoA:3-oxoacid CoA-transferase; succinyl CoA:3-oxoacid CoA transferase; succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial; succinyl-CoA:3-ketoacid-CoA transferase
Description (eCommerce)
OXCT1 is a key enzyme for ketone body catabolism. OXCT1 transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P55809].
Description (Vector)
OXCT1 encodes a member of the 3-oxoacid CoA-transferase gene family. The encoded protein is a homodimeric mitochondrial matrix enzyme that plays a central role in extrahepatic ketone body catabolism by catalyzing the reversible transfer of coenzyme A from succinyl-CoA to acetoacetate. Mutations in this gene are associated with succinyl CoA:3-oxoacid CoA transferase deficiency.
Gene ID
5019
Gene Name (eCommerce)
3-oxoacid CoA-transferase 1
Gene Name (Vector)
3-oxoacid CoA-transferase 1
Gene Symbol
OXCT1
HGNC ID
HGNC:8527
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1563
ORF Size (bp)
1563 bp
Protein Name (eCommerce)
Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial
RefSeq ID
NM_000436
RefSeq Synonyms
NM_000436, BC009001,
Research Areas
Metabolism/Metabolic Process,Mitochondrion
Research Areas (Faceted)
cell_biology,metabolism
Species
human
Target Sentence
OXCT1 is a key enzyme for ketone body catabolism. OXCT1 transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P55809].
UniGene ID
Hs.278277
UniProt ID (eCommerce)
P55809

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.