human OTUD5 Over-expression AAV

Name 
AAV-h-OTUD5
Cat No 
AAV-218002
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human OTUD5.

AAV-218002
AAV-h-OTUD5

Ready-to-use AAV expressing Human OTUD5 (OTU deubiquitinase 5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
deubiquinating enzyme A; deubiquitinating enzyme A; DUBA; OTU domain containing 5; OTU domain-containing protein 5
Description (eCommerce)
Deubiquitinating enzyme A (DUBA) is a negative regulator of the innate immune system. DUBA has deubiquitinating activity that is directed towards 'Lys-63'-linked polyubiquitin chains and acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q96G74].
Description (Vector)
OTUD5 encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described.
Gene ID
55593
Gene Name (eCommerce)
OTU deubiquitinase 5
Gene Name (Vector)
OTU deubiquitinase 5
Gene Symbol
OTUD5
HGNC ID
HGNC:25402
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1629
ORF Size (bp)
1629 bp
Protein Name (eCommerce)
OTU domain-containing protein 5
RefSeq ID
NM_017602
RefSeq Synonyms
NM_017602, NM_001136159, NM_001136158, NM_001136157, BC098440, BC028225, BC009917,
Research Areas
Cancer,IFN Signaling,Immunology,Innate Immunity,Signal Transduction,Toll-like Receptor Signaling,Ubiquitination
Research Areas (Faceted)
cancer,cell_biology,immunology,signal_transduction
Species
human
Target Sentence
Deubiquitinating enzyme A (DUBA) is a negative regulator of the innate immune system. DUBA has deubiquitinating activity that is directed towards 'Lys-63'-linked polyubiquitin chains and acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q96G74].
UniGene ID
Hs.496098
UniProt ID (eCommerce)
Q96G74

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.