human NR1I3 Over-expression AAV
Category: AAV > Over-Expression
Cat. No: AAV-217041
Availability:
3-5 weeks
Name:
AAV-h-NR1I3
This is an AAV expressing Human NR1I3.
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Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- CMV (default), or choose from 30 different ubiquitous or cell specific promoter
- Reporter
- none, optional GFP, CFP, YFP, RFP or mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- NR1I3
- Gene Name
- nuclear receptor subfamily 1 group I member 3
- Gene ID
- 9970
- Gene Synonyms
- CAR; CAR1; MB67
- ORF Size
- 945 bp
- RefSeq#
- BC121120
- Gene Description
- NR1I3 encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene.
- UniGene ID
- Hs.349642
- HGNC ID
- HGNC:7969
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