human NLRP8 Over-expression AAV

Name
AAV-h-NLRP8

Cat No
AAV-216808

Availability
4-5 weeks

This is an AAV expressing Human NLRP8.

AAV-216808

AAV-h-NLRP8

Ready-to-use AAV expressing Human NLRP8 (NLR family pyrin domain containing 8). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CLR19.2; NALP8; NOD16; PAN4

Description (Vector)

NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP8, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 (PubMed 12563287)).(supplied by OMIM, Mar 2008)

Gene ID

126205

Gene Name (Vector)

NLR family pyrin domain containing 8

Gene Symbol

NLRP8

HGNC ID

HGNC:22940

ORF Size (aa)

3144

ORF Size (bp)

3144 bp

RefSeq ID

NM_176811

RefSeq Synonyms

NM_176811, NM_001317000, BC153174, BC148608,

Species

human

UniGene ID

Hs.446925

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.