human NLRC4 Over-expression AAV

Name 
AAV-h-NLRC4
Cat No 
AAV-216787
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human NLRC4.

AAV-216787
AAV-h-NLRC4

Ready-to-use AAV expressing Human NLRC4 (NLR family CARD domain containing 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
AIFEC; CARD12; CLAN; CLAN1; CLANA; CLANB; CLANC; CLAND; CLR2.1; FCAS4; IPAF
Description (Vector)
In C. elegans, Ced4 binds and activates Ced3, an apoptotic initiator caspase, via caspase-associated recruitment domains (CARDs). Human Ced4 homologs include APAF1 (MIM 602233), NOD1/CARD4 (MIM 605980), and NOD2/CARD15 (MIM 605956). These proteins have at least 1 N-terminal CARD domain followed by a centrally located nucleotide-binding domain (NBD or NACHT) and a C-terminal regulatory domain, found only in mammals, that contains either WD40 repeats or leucine-rich repeats (LRRs). CARD12 is a member of the Ced4 family and can induce apoptosis.(supplied by OMIM, Mar 2008)
Gene ID
58484
Gene Name (Vector)
NLR family CARD domain containing 4
Gene Symbol
NLRC4
HGNC ID
HGNC:16412
ORF Size (aa)
3075
ORF Size (bp)
3075 bp
RefSeq ID
NM_021209
RefSeq Synonyms
NM_021209, NM_001302504, NM_001199139, NM_001199138, BC031555,
Species
human
UniGene ID
Hs.574741

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.