human NFKBIZ Over-expression AAV
Category: AAV > Over-Expression
Cat. No: AAV-216657
Availability:
3-5 weeks
Name:
AAV-h-NFKBIZ
This is an AAV expressing Human NFKBIZ.
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Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- CMV (default), or choose from 30 different ubiquitous or cell specific promoter
- Reporter
- none, optional GFP, CFP, YFP, RFP or mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- NFKBIZ
- Gene Name
- NFKB inhibitor zeta
- Gene ID
- 64332
- Gene Synonyms
- IKBZ; INAP; MAIL
- ORF Size
- 2157 bp
- RefSeq#
- BC060800
- Gene Description
- NFKBIZ is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-B proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been found for this gene.
- UniGene ID
- Hs.319171
- HGNC ID
- HGNC:29805
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