human NFATC4 Over-expression AAV
This is an AAV expressing Human NFATC4.
AAV-216635
AAV-h-NFATC4
Ready-to-use AAV expressing Human NFATC4 (nuclear factor of activated T-cells 4). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
NFAT3; NF-AT3; NFATc4; NF-ATC4; nuclear factor of activated T-cells, cytoplasmic 4; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4; T-cell transcription factor NFAT3
Description (eCommerce)
NFAT3 (nuclear factor of activated T-cells 3) plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 and IL-4. NFAT3 is transcriptionally repressed by estrogen receptors; this inhibition is further enhanced by estrogen. NFAT3 increases the transcriptional activity of PPARG and has a direct role in adipocyte differentiation. It may also play an important role in myotube differentiation, cardiac development and hypertrophy, and in deafferentation-induced apoptosis of sensory neurons [taken from the Universal Protein Resource (UniProt) ww.uniprot.org/uniprot/Q14934].
Description (Vector)
The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family of nuclear factors of activated T cells also participate in the formation of this complex. The product of this gene plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of the IL-2 and IL-4. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Gene ID
4776
Gene Name (eCommerce)
nuclear factor of activated T cells 4
Gene Name (Vector)
nuclear factor of activated T-cells 4
Gene Symbol
NFATC4
HGNC ID
HGNC:7778
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2709
ORF Size (bp)
2709 bp
Protein Name (eCommerce)
Nuclear factor of activated T-cells, cytoplasmic 4
RefSeq ID
NM_004554
RefSeq Synonyms
NM_004554, NM_001320043, NM_001288802, NM_001198967, NM_001198966, NM_001198965, NM_001136022, BC053855,
Research Areas
Apoptosis,Axon Guidance,BDNF Signaling,Cancer,Cardiac Development,Cardiac Hypertrophy,Cardiology,Cardiovascular,Cytoskeleton,Host-Virus Interactions,Immunology,Neurobiology,RNA Binding,Signal Transduction,Transcription Factor/Regulator,Wnt Signaling
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,developmental_biology,immunology,infectious_disease,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
NFAT3 (nuclear factor of activated T-cells 3) plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 and IL-4. NFAT3 is transcriptionally repressed by estrogen receptors; this inhibition is further enhanced by estrogen. NFAT3 increases the transcriptional activity of PPARG and has a direct role in adipocyte differentiation. It may also play an important role in myotube differentiation, cardiac development and hypertrophy, and in deafferentation-induced apoptosis of sensory neurons [taken from the Universal Protein Resource (UniProt) ww.uniprot.org/uniprot/Q14934].
UniGene ID
Hs.77810
UniProt ID (eCommerce)
Q14934
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.