human NCSTN Over-expression AAV

Name 
AAV-h-NCSTN
Cat No 
AAV-216441
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human NCSTN.

AAV-216441
AAV-h-NCSTN

Ready-to-use AAV expressing Human NCSTN (nicastrin). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
anterior pharynx-defective 2; ATAG1874; nicastrin
Description (eCommerce)
Nicastrin is an essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q92542].
Description (Vector)
NCSTN encodes a Type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Alternatively spliced transcript variants have been described, but their full-length nature has not been determined.
Gene ID
23385
Gene Name (eCommerce)
nicastrin
Gene Name (Vector)
nicastrin
Gene Symbol
NCSTN
HGNC ID
HGNC:17091
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2070
ORF Size (bp)
2070 bp
Protein Name (eCommerce)
Nicastrin
RefSeq ID
NM_015331
RefSeq Synonyms
NM_015331, NM_001290186, NM_001290184, BC047621,
Research Areas
Alzheimer's Disease,Apoptosis,Cancer,Golgi Apparatus,Immunology,Neurobiology,Neurodegeneration,NGF Signaling,Notch Signaling,Signal Transduction,Toll-like Receptor Signaling,Wnt Signaling
Research Areas (Faceted)
cancer,cell_biology,developmental_biology,immunology,neurobiology,signal_transduction
Species
human
Target Sentence
Nicastrin is an essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q92542].
UniGene ID
Hs.517249
UniProt ID (eCommerce)
Q92542

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.