human BRD3 Over-expression AAV

Name 
AAV-h-BRD3
Cat No 
AAV-216435
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human BRD3.

AAV-216435
AAV-h-BRD3

Ready-to-use AAV expressing Human BRD3 (bromodomain containing 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
bromodomain-containing protein 3; bromodomain-containing protein 3 short isoform; ORFX; RING3L; RING3-like protein
Description (eCommerce)
BRD3 (bromodomain containing 3) is a double bromo-domain containing protein. It has been shown to associate with hyperacetylated chromatin of transcribed genes. From this finding it is suggested that BRD3 plays a role in RNA polymerase II transcription through nucleosomes. A chromosomal translocation resulting in a fusion protein involving BRD3 and NUT has been associated with a rare and lethal carcinoma. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q15059 and from NCBI Entrez Gene (Gene ID: 8019)].
Description (Vector)
BRD3 was identified based on its homology to the gene encoding the RING3 protein, a serine/threonine kinase. The gene localizes to 9q34, a region which contains several major histocompatibility complex (MHC) genes. The function of the encoded protein is not known.
Gene ID
8019
Gene Name (eCommerce)
bromodomain containing 3
Gene Name (Vector)
bromodomain containing 3
Gene Symbol
BRD3
HGNC ID
HGNC:1104
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1671
ORF Size (bp)
1671 bp
Protein Name (eCommerce)
Bromodomain-containing protein 3
RefSeq ID
NM_007371
RefSeq Synonyms
NM_007371, BC032124,
Research Areas
Chromatin Remodeling,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,genetics,transcription_translation
Species
human
Target Sentence
BRD3 (bromodomain containing 3) is a double bromo-domain containing protein. It has been shown to associate with hyperacetylated chromatin of transcribed genes. From this finding it is suggested that BRD3 plays a role in RNA polymerase II transcription through nucleosomes. A chromosomal translocation resulting in a fusion protein involving BRD3 and NUT has been associated with a rare and lethal carcinoma. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q15059 and from NCBI Entrez Gene (Gene ID: 8019)].
UniGene ID
Hs.654869
UniProt ID (eCommerce)
Q15059

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.