human NARF Over-expression AAV
This is an AAV expressing Human NARF.
AAV-216321
AAV-h-NARF
Ready-to-use AAV expressing Human NARF (nuclear prelamin A recognition factor). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
IOP2
Description (Vector)
Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A. The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex. The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina. It shares limited sequence similarity with iron-only bacterial hydrogenases. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene, including one with a novel exon that is generated by RNA editing.
Gene ID
26502
Gene Name (Vector)
nuclear prelamin A recognition factor
Gene Symbol
NARF
HGNC ID
HGNC:29916
ORF Size (aa)
1509
ORF Size (bp)
1509 bp
RefSeq ID
NM_012336
RefSeq Synonyms
NM_031968, NM_012336, NM_001083608, NM_001038618, BC016440, BC000438,
Species
human
UniGene ID
Hs.600304
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.