human MTA3 Over-expression AAV

Name 
AAV-h-MTA3
Cat No 
AAV-215966
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human MTA3.

AAV-215966
AAV-h-MTA3

Ready-to-use AAV expressing Human MTA3 (metastasis associated 1 family member 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
metastasis associated gene family, member 3; metastasis-associated protein MTA3
Description (eCommerce)
MTA3 (metastasis-associated protein 3) is a component of the NuRD (nucleosome remodeling and histone deacetylation) complex. MTA3 is a member of a family of proteins (MTA1-3) differentially expressed in metastatic breast cancer cells. MTA3 functions as a repressor of the transcription factor Snail, a factor involved in epithelial to mesenchymal transitions. MTA3 expression is estrogen dependent in breast cancer cells. Studies show that ERalpha selectively bind the MTA3 promoter in an SP1-dependent fashion to stimulate MTA3 gene transcription.
Gene ID
57504
Gene Name (eCommerce)
metastasis associated 1 family member 3
Gene Name (Vector)
metastasis associated 1 family member 3
Gene Symbol
MTA3
HGNC ID
HGNC:23784
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1548
ORF Size (bp)
1548 bp
Protein Name (eCommerce)
Metastasis-associated protein MTA3
RefSeq ID
NM_020744
RefSeq Synonyms
NM_020744, NM_001330444, NM_001330443, NM_001330442, NM_001282756, NM_001282755, BC053631, BC004227,
Research Areas
Breast Cancer,Cancer,Transcription Factor/Regulator,Zinc-finger
Research Areas (Faceted)
cancer,cell_biology,transcription_translation
Species
human
Target Sentence
MTA3 (metastasis-associated protein 3) is a component of the NuRD (nucleosome remodeling and histone deacetylation) complex. MTA3 is a member of a family of proteins (MTA1-3) differentially expressed in metastatic breast cancer cells. MTA3 functions as a repressor of the transcription factor Snail, a factor involved in epithelial to mesenchymal transitions. MTA3 expression is estrogen dependent in breast cancer cells. Studies show that ERalpha selectively bind the MTA3 promoter in an SP1-dependent fashion to stimulate MTA3 gene transcription.
UniGene ID
Hs.435413
UniProt ID (eCommerce)
Q9BTC8

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.