human MATR3 Over-expression AAV

Name 
AAV-h-MATR3
Cat No 
AAV-215076
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human MATR3.

AAV-215076
AAV-h-MATR3

Ready-to-use AAV expressing Human MATR3 (matrin 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
ALS21; matrin-3; MPD2; VCPDM; vocal cord and pharyngeal weakness with distal myopathY
Description (eCommerce)
Matrin 3 is a nuclear matrix protein that has been observed to mediate multiple cellular processes. Matrin 3 can function to withhold defective RNAs within the nucleus by anchoring them to the nuclear matrix and modulate the promoter activity of genes proximal to matrix/scaffold attachment region (MAR/SAR). Matrin 3 has also been demonstrated to be the main PKA substrate following NMDA receptor activation in NMDA-induced neuronal cell death.
Description (Vector)
This locus encodes a nuclear matrix protein. Mutations at this locus have been associated with distal myopathy 2, which often includes vocal cord and pharyngeal weakness. Alternatively spliced transcript variants, including read-through transcripts with an upstream locus have been described. Related pseuodgenes have been defined on chr1 and chrX.
Gene ID
9782
Gene Name (eCommerce)
matrin 3
Gene Name (Vector)
matrin 3
Gene Symbol
MATR3
HGNC ID
HGNC:6912
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2544
ORF Size (bp)
2544 bp
Protein Name (eCommerce)
Matrin-3
RefSeq ID
NM_018834
RefSeq Synonyms
NM_199189, NM_018834, NM_001282278, NM_001194956, NM_001194955, NM_001194954, BC015031,
Research Areas
Immunology,RNA Binding,RNA Processing,Zinc-finger
Research Areas (Faceted)
immunology,genetics,transcription_translation,cell_biology
Species
human
Target Sentence
Matrin 3 is a nuclear matrix protein that has been observed to mediate multiple cellular processes. Matrin 3 can function to withhold defective RNAs within the nucleus by anchoring them to the nuclear matrix and modulate the promoter activity of genes proximal to matrix/scaffold attachment region (MAR/SAR). Matrin 3 has also been demonstrated to be the main PKA substrate following NMDA receptor activation in NMDA-induced neuronal cell death.
UniGene ID
Hs.268939
UniProt ID (eCommerce)
P43243

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.