human MAPK8 Over-expression AAV

Name 
AAV-h-MAPK8
Cat No 
AAV-214985
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human MAPK8.

AAV-214985
AAV-h-MAPK8

Ready-to-use AAV expressing Human MAPK8 (mitogen-activated protein kinase 8). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2; PRKM8; SAPK1; SAPK1c
Description (Vector)
MAPK8 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
Gene ID
5599
Gene Name (Vector)
mitogen-activated protein kinase 8
Gene Symbol
MAPK8
HGNC ID
HGNC:6881
ORF Size (aa)
1155
ORF Size (bp)
1155 bp
RefSeq ID
NM_139049
RefSeq Synonyms
NM_139049, NM_139047, NM_139046, NM_002750, NM_001323331, NM_001323330, NM_001323329, NM_001323328, NM_001323327, NM_001323326, NM_001323325, NM_001323324, NM_001323323, NM_001323322, NM_001323321, NM_001323320, NM_001323302, NM_001278548, NM_001278547, BC144063, BC130572, BC130570,
Species
human
UniGene ID
Hs.138211

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.