human LRP8 Over-expression AAV

Name 
AAV-h-LRP8
Cat No 
AAV-214510
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human LRP8.

AAV-214510
AAV-h-LRP8

Ready-to-use AAV expressing Human LRP8 (LDL receptor related protein 8). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
APOER2; HSZ75190; LRP-8; MCI1
Description (Vector)
LRP8 encodes a member of the low density lipoprotein receptor (LDLR) family. Low density lipoprotein receptors are cell surface proteins that play roles in both signal transduction and receptor-mediated endocytosis of specific ligands for lysosomal degradation. The encoded protein plays a critical role in the migration of neurons during development by mediating Reelin signaling, and also functions as a receptor for the cholesterol transport protein apolipoprotein E. Expression of this gene may be a marker for major depressive disorder. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Gene ID
7804
Gene Name (Vector)
LDL receptor related protein 8
Gene Symbol
LRP8
HGNC ID
HGNC:6700
ORF Size (aa)
2715
ORF Size (bp)
2715 bp
RefSeq ID
NM_004631
RefSeq Synonyms
NM_033300, NM_017522, NM_004631, NM_001018054, BC051836,
Species
human
UniGene ID
Hs.576154

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.