human MIB2 Over-expression AAV

Name
AAV-h-MIB2

Cat No
AAV-214074

Availability
4-5 weeks

This is an AAV expressing Human MIB2.

AAV-214074

AAV-h-MIB2

Ready-to-use AAV expressing Human MIB2 (mindbomb E3 ubiquitin protein ligase 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

E3 ubiquitin-protein ligase MIB2; mind bomb homolog 2; mindbomb homolog 2; novel zinc finger protein; novelzin; putative NF-kappa-B-activating protein 002N; RING-type E3 ubiquitin transferase MIB2; skeletrophin; zinc finger ZZ type with ankyrin repeat domain protein 1; zinc finger, ZZ type with ankyrin repeat domain 1; ZZANK1; ZZZ5

Description (eCommerce)

MIB2/Skeletrophin is an actin-binding protein that bears two MIB/HERC2 domains, a ZZ-type zinc-finger domain, nine ankyrin repeats, and two RING-finger domains. The C-terminal RING domain has been found to have E3 ubiquitin ligase activity that mediates ubiquitination of the intracellular regions of the Notch receptor and its ligands to regulate Notch signaling. MIB2/Skeletrophin appears to be important to muscle development and may function as a suppressor of melanoma invasion.

Gene ID

142678

Gene Name (eCommerce)

mindbomb E3 ubiquitin protein ligase 2

Gene Name (Vector)

mindbomb E3 ubiquitin protein ligase 2

Gene Symbol

MIB2

HGNC ID

HGNC:30577

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

3000

ORF Size (bp)

3000 bp

Protein Name (eCommerce)

E3 ubiquitin-protein ligase MIB2

RefSeq ID

NM_080875

RefSeq Synonyms

NM_080875, NM_001170689, NM_001170688, NM_001170687, NM_001170686, BC037542,

Research Areas

Cancer,NF-kB Signaling,Notch Signaling,Signal Transduction,Ubiquitination,Zinc-finger

Research Areas (Faceted)

cancer,cell_biology,developmental_biology,signal_transduction

Species

human

Target Sentence

MIB2/Skeletrophin is an actin-binding protein that bears two MIB/HERC2 domains, a ZZ-type zinc-finger domain, nine ankyrin repeats, and two RING-finger domains. The C-terminal RING domain has been found to have E3 ubiquitin ligase activity that mediates ubiquitination of the intracellular regions of the Notch receptor and its ligands to regulate Notch signaling. MIB2/Skeletrophin appears to be important to muscle development and may function as a suppressor of melanoma invasion.

UniGene ID

Hs.135805

UniProt ID (eCommerce)

Q96AX9

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.