human LATS2 Over-expression AAV

Name
AAV-h-LATS2

Cat No
AAV-213707

Availability
4-5 weeks

This is an AAV expressing Human LATS2.

AAV-213707

AAV-h-LATS2

Ready-to-use AAV expressing Human LATS2 (large tumor suppressor kinase 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

KPM

Description (Vector)

LATS2 encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression.

Gene ID

26524

Gene Name (Vector)

large tumor suppressor kinase 2

Gene Symbol

LATS2

HGNC ID

HGNC:6515

ORF Size (aa)

3264

ORF Size (bp)

3264 bp

RefSeq ID

NM_014572

RefSeq Synonyms

NM_014572, BC172545, BC156423,

Species

human

UniGene ID

Hs.78960

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.