human IST1 Over-expression AAV

Name
AAV-h-IST1

Cat No
AAV-212890

Availability
4-5 weeks

This is an AAV expressing Human IST1.

AAV-212890

AAV-h-IST1

Ready-to-use AAV expressing Human IST1 (IST1, ESCRT-III associated factor). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

hIST1; increased sodium tolerance 1 homolog; IST1 homolog; IST1, endosomal sorting complex required for transport-III component; OLC1; overexpressed in lung cancer 1; putative MAPK-activating protein PM28

Description (eCommerce)

Increased sodium tolerance 1 homolog (IST1) is a protein with MIT-interacting motifs that interacts with components of endosomal sorting complexes required for transport (ESCRT). ESCRT functions in vesicle budding, such as that which occurs during membrane abscission in cytokinesis [taken from NCBI Entrez Gene (Gene ID: 9798)].

Description (Vector)

IST1 encodes a protein with MIT-interacting motifs that interacts with components of endosomal sorting complexes required for transport (ESCRT). ESCRT functions in vesicle budding, such as that which occurs during membrane abscission in cytokinesis. There is a pseudogene for this gene on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene ID

9798

Gene Name (eCommerce)

IST1, ESCRT-III associated factor

Gene Name (Vector)

IST1, ESCRT-III associated factor

Gene Symbol

IST1

HGNC ID

HGNC:28977

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1083

ORF Size (bp)

1083 bp

Protein Name (eCommerce)

IST1 homolog

RefSeq ID

NM_014761

RefSeq Synonyms

NM_014761, NM_001270979, NM_001270978, NM_001270977, NM_001270976, NM_001270975, BC103745, BC004359, BC000430, BC000116,

Research Areas

Cell Cycle,Cell Division,Golgi Apparatus

Research Areas (Faceted)

cell_biology,cell_cycle,genetics

Species

human

Target Sentence

Increased sodium tolerance 1 homolog (IST1) is a protein with MIT-interacting motifs that interacts with components of endosomal sorting complexes required for transport (ESCRT). ESCRT functions in vesicle budding, such as that which occurs during membrane abscission in cytokinesis [taken from NCBI Entrez Gene (Gene ID: 9798)].

UniGene ID

Hs.232194

UniProt ID (eCommerce)

P53990

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.