human KCNJ11 Over-expression AAV

Name
AAV-h-KCNJ11

Cat No
AAV-212712

Availability
4-5 weeks

This is an AAV expressing Human KCNJ11.

AAV-212712

AAV-h-KCNJ11

Ready-to-use AAV expressing Human KCNJ11 (potassium voltage-gated channel subfamily J member 11). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

BIR; HHF2; IKATP; KIR6.2; MODY13; PHHI; TNDM3

Description (Vector)

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.

Gene ID

3767

Gene Name (Vector)

potassium voltage-gated channel subfamily J member 11

Gene Symbol

KCNJ11

HGNC ID

HGNC:6257

ORF Size (aa)

1173

ORF Size (bp)

1173 bp

RefSeq ID

NM_000525

RefSeq Synonyms

NM_001166290, NM_000525, BC112358, BC064497,

Species

human

UniGene ID

Hs.248141

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.