human EIF2AK1 Over-expression AAV
This is an AAV expressing Human EIF2AK1.
AAV-212603
AAV-h-EIF2AK1
Ready-to-use AAV expressing Human EIF2AK1 (eukaryotic translation initiation factor 2 alpha kinase 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
eukaryotic translation initiation factor 2-alpha kinase 1; HCR; heme regulated initiation factor 2 alpha kinase; heme sensitive initiation factor 2a kinase; heme-controlled repressor; heme-regulated eukaryotic initiation factor eIF-2-alpha kinase; heme-regulated inhibitor; heme-regulated repressor; hemin-sensitive initiation factor 2-alpha kinase; HRI
Description (eCommerce)
Eukaryotic translation initiation factor 2-alpha kinase 1 (EIF2AK1) is also known as Heme-regulated inhibitor (HRI). EIF2AK1 is regulated and inactivated by Hemin. EIF2AK1 Mediates down-regulation of protein synthesis in response to various stress conditions by the phosphorylation of eIF-2alpha at 'Ser-48' and 'Ser-51'.
Description (Vector)
EIF2AK1 acts at the level of translation initiation to downregulate protein synthesis in response to stress. The encoded protein is a kinase that can be inactivated by hemin. Two transcript variants encoding different isoforms have been found for this gene.
Gene ID
27102
Gene Name (eCommerce)
eukaryotic translation initiation factor 2 alpha kinase 1
Gene Name (Vector)
eukaryotic translation initiation factor 2 alpha kinase 1
Gene Symbol
EIF2AK1
HGNC ID
HGNC:24921
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1893
ORF Size (bp)
1893 bp
Protein Name (eCommerce)
Eukaryotic translation initiation factor 2-alpha kinase 1
RefSeq ID
NM_014413
RefSeq Synonyms
NM_014413, NM_001134335, BC006524,
Research Areas
Host-Virus Interactions,Kinase/Phosphatase,Translational Control
Research Areas (Faceted)
cell_biology,infectious_disease,signal_transduction,transcription_translation
Species
human
Target Sentence
Eukaryotic translation initiation factor 2-alpha kinase 1 (EIF2AK1) is also known as Heme-regulated inhibitor (HRI). EIF2AK1 is regulated and inactivated by Hemin. EIF2AK1 Mediates down-regulation of protein synthesis in response to various stress conditions by the phosphorylation of eIF-2alpha at 'Ser-48' and 'Ser-51'.
UniGene ID
Hs.520205
UniProt ID (eCommerce)
Q9BQI3
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.