human ITGA6 Over-expression AAV

Name 
AAV-h-ITGA6
Cat No 
AAV-212483
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human ITGA6.

AAV-212483
AAV-h-ITGA6

Ready-to-use AAV expressing Human ITGA6 (integrin subunit alpha 6). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CD antigen CD49f; CD49 antigen-like family member F; CD49f; integrin alpha-6; integrin alpha6B; integrin, alpha 6; ITGA6B; VLA-6
Description (eCommerce)
Integrin alpha 6 forms heterodimers with integrin beta 1 or beta 4 and functions as a receptor for the extracellular matrix protein, laminin. Integrin alpha 6 is encoded by the ITGA6 gene. Defects in ITGA6 are a cause of epidermolysis bullosa letalis with pyloric atresia (EB-PA) [MIM:226730]; also known as junctional epidermolysis bullosa with pyloric atresia (PA-JEB) or aplasia cutis congenita with gastrointestinal atresia. EB-PA is an autosomal recessive, frequently lethal, epidermolysis bullosa with variable involvement of skin, nails, mucosa, and with variable effects on the digestive system [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ P23229].
Description (Vector)
The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene.
Gene ID
3655
Gene Name (eCommerce)
integrin subunit alpha 6
Gene Name (Vector)
integrin subunit alpha 6
Gene Symbol
ITGA6
HGNC ID
HGNC:6142
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3222
ORF Size (bp)
3222 bp
Protein Name (eCommerce)
Integrin alpha-6
RefSeq ID
NM_000210
RefSeq Synonyms
NM_001316306, NM_001079818, NM_000210, BC136456, BC136455,
Research Areas
Apoptosis,Cancer,Cardiology,Cardiomyopathy,Cardiovascular,Cytoskeleton,Immunology,Lung Cancer,PI3K/Akt Signaling,Signal Transduction
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,immunology,signal_transduction
Species
human
Target Sentence
Integrin alpha 6 forms heterodimers with integrin beta 1 or beta 4 and functions as a receptor for the extracellular matrix protein, laminin. Integrin alpha 6 is encoded by the ITGA6 gene. Defects in ITGA6 are a cause of epidermolysis bullosa letalis with pyloric atresia (EB-PA) [MIM:226730]; also known as junctional epidermolysis bullosa with pyloric atresia (PA-JEB) or aplasia cutis congenita with gastrointestinal atresia. EB-PA is an autosomal recessive, frequently lethal, epidermolysis bullosa with variable involvement of skin, nails, mucosa, and with variable effects on the digestive system [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ P23229].
UniGene ID
Hs.133397
UniProt ID (eCommerce)
P23229

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.