human ISCU Over-expression AAV

Name
AAV-h-ISCU

Cat No
AAV-212433

Availability
4-5 weeks

This is an AAV expressing Human ISCU.

AAV-212433

AAV-h-ISCU

Ready-to-use AAV expressing Human ISCU (iron-sulfur cluster assembly enzyme). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

2310020H20Rik; HML; hnifU; ISU2; NIFU; NIFUN

Description (Vector)

Iron-sulfur (Fe-S) clusters are necessary for several mitochondrial enzymes and other subcellular compartment proteins. They contain sulfur and iron, and are created via several steps that include cysteine desulfurases, iron donors, chaperones, and scaffold proteins. This gene encodes the two isomeric forms, ISCU1 and ISCU2, of the Fe-S cluster scaffold protein. Mutations in this gene have been found in patients with myopathy with severe exercise intolerance and myoglobinuria.

Gene ID

23479

Gene Name (Vector)

iron-sulfur cluster assembly enzyme

Gene Symbol

ISCU

HGNC ID

HGNC:29882

ORF Size (aa)

504

RefSeq ID

NM_014301

RefSeq Synonyms

NM_213595, NM_014301, NM_001320042, NM_001301141, NM_001301140, BC061903, BC011906,

Species

human

UniGene ID

Hs.711414

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.