human IKZF1 Over-expression AAV

CLL-associated antigen KW-6; CVID13; DNA-binding protein Ikaros; Hs.54452; IK1; IKAROS; ikaros family zinc finger protein 1; LYF1; LyF-1; lymphoid transcription factor LyF-1; PPP1R92; PRO0758; protein phosphatase 1, regulatory subunit 92; zinc finger protein, subfamily 1A, 1 (Ikaros); ZNFN1A1

DNA-binding protein Ikaros is a transcriptional regulator of hematopoietic cell differentiation. It exists as multiple isoforms lending complexity to its function.

IKZF1 encodes a transcription factor that belongs to the family of zinc-finger DNA binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. All isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homodimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and contain the nuclear localization signal, resulting in members with and without DNA-binding properties. Only few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and thought to function as dominant negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL).

10320

IKAROS family zinc finger 1

IKAROS family zinc finger 1 (Ikaros)

IKZF1

HGNC:13176

9606.0

1434

1434 bp

DNA-binding protein Ikaros

NM_006060

NM_006060, NM_001291847, NM_001291846, NM_001291845, NM_001291844, NM_001291843, NM_001291842, NM_001291841, NM_001291840, NM_001291839, NM_001291838, NM_001291837, NM_001220776, NM_001220775, NM_001220774, NM_001220773, NM_001220772, NM_001220771, NM_001220770, NM_001220769, NM_001220768, NM_001220767, NM_001220766, NM_001220765, BC018349,

Brain Development,Cancer,Cell Cycle,Chromatin Remodeling,Immunology,Kinase/Phosphatase,Neurobiology,Neurodevelopment,Transcription Factor/Regulator,Tumor Suppressors/Oncoproteins,Zinc-finger

cancer,cell_biology,cell_cycle,developmental_biology,genetics,immunology,neurobiology,signal_transduction,transcription_translation

human

DNA-binding protein Ikaros is a transcriptional regulator of hematopoietic cell differentiation. It exists as multiple isoforms lending complexity to its function.

Hs.488251

Q13422