human IDS Over-expression AAV

Name
AAV-h-IDS

Cat No
AAV-211780

Availability
4-5 weeks

This is an AAV expressing Human IDS.

AAV-211780

AAV-h-IDS

Ready-to-use AAV expressing Human IDS (iduronate 2-sulfatase). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

MPS2; SIDS

Description (Vector)

Iduronate-2-sulfatase is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this X-chromosome gene that result in enzymatic deficiency lead to the sex-linked Mucopolysaccharidosis Type II, also known as Hunter Syndrome. Iduronate-2-sulfatase has a strong sequence similarity with human arylsulfatases A, B, and C, and human glucosamine-6-sulfatase. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described.

Gene ID

3423

Gene Name (Vector)

iduronate 2-sulfatase

Gene Symbol

IDS

HGNC ID

HGNC:5389

ORF Size (aa)

939

ORF Size (bp)

939 bp

RefSeq ID

NM_000202

RefSeq Synonyms

NM_006123, NM_001166550, NM_000202, BC006170,

Species

human

UniGene ID

Hs.460960

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.