human IDH2 Over-expression AAV

Name 
AAV-h-IDH2
Cat No 
AAV-211771
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human IDH2.

AAV-211771
AAV-h-IDH2

Ready-to-use AAV expressing Human IDH2 (isocitrate dehydrogenase (NADP(+)) 2, mitochondrial). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
D2HGA2; ICD-M; IDH; IDHM; IDP; IDPM; isocitrate dehydrogenase NADP, mitochondrial; isocitrate dehydrogenase 2 (NADP+), mitochondrial; mNADP-IDH; NADP(+)-specific ICDH; oxalosuccinate decarboxylase
Description (eCommerce)
Isocitrate dehydrogenase 2 (NADP+), mitochondrial (IDH2) plays a role in intermediary metabolism and energy production. IDH2 may tightly associate or interact with the pyruvate dehydrogenase complex [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P48735].
Description (Vector)
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex.
Gene ID
3418
Gene Name (eCommerce)
isocitrate dehydrogenase (NADP(+)) 2, mitochondrial
Gene Name (Vector)
isocitrate dehydrogenase (NADP(+)) 2, mitochondrial
Gene Symbol
IDH2
HGNC ID
HGNC:5383
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1359
ORF Size (bp)
1359 bp
Protein Name (eCommerce)
Isocitrate dehydrogenase [NADP], mitochondrial
RefSeq ID
NM_002168
RefSeq Synonyms
NM_002168, NM_001290114, NM_001289910, BC071828, BC009244,
Research Areas
Metabolism/Metabolic Process,Mitochondrion
Research Areas (Faceted)
cell_biology,metabolism
Species
human
Target Sentence
Isocitrate dehydrogenase 2 (NADP+), mitochondrial (IDH2) plays a role in intermediary metabolism and energy production. IDH2 may tightly associate or interact with the pyruvate dehydrogenase complex [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P48735].
UniGene ID
Hs.596461
UniProt ID (eCommerce)
P48735

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.