human HMGCS2 Over-expression AAV

Name
AAV-h-HMGCS2

Cat No
AAV-211285

Availability
4-5 weeks

This is an AAV expressing Human HMGCS2.

AAV-211285

AAV-h-HMGCS2

Ready-to-use AAV expressing Human HMGCS2 (3-hydroxy-3-methylglutaryl-CoA synthase 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Description (Vector)

HMGCS2 belongs to the HMG-CoA synthase family. It is a mitochondrial enzyme that catalyzes the first reaction of ketogenesis, a metabolic pathway that provides lipid-derived energy for various organs during times of carbohydrate deprivation, such as fasting. Mutations in this gene are associated with HMG-CoA synthase deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene ID

3158

Gene Name (Vector)

3-hydroxy-3-methylglutaryl-CoA synthase 2

Gene Symbol

HMGCS2

HGNC ID

HGNC:5008

ORF Size (aa)

1527

ORF Size (bp)

1527 bp

RefSeq ID

NM_005518

RefSeq Synonyms

NM_005518, NM_001166107, BC044217,

Species

human

UniGene ID

Hs.59889

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.