human HIF1AN Over-expression AAV

Name 
AAV-h-HIF1AN
Cat No 
AAV-211020
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human HIF1AN.

AAV-211020
AAV-h-HIF1AN

Ready-to-use AAV expressing Human HIF1AN (hypoxia inducible factor 1 alpha subunit inhibitor). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
factor inhibiting HIF1; factor inhibiting HIF-1; FIH1; FIH-1; hypoxia inducible factor 1 alpha subunit inhibitor; hypoxia-inducible factor 1-alpha inhibitor; hypoxia-inducible factor asparagine hydroxylase; peptide-aspartate beta-dioxygenase
Description (eCommerce)
Factor inhibiting HIF-1 (FIH-1) hydroxylates HIF-1 alpha at 'Asp-803' in the C-terminal transactivation domain (CAD). FIH-1 functions as an oxygen sensor, and under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. FIH-1 is involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9NWT6].
Gene ID
55662
Gene Name (eCommerce)
hypoxia inducible factor 1 subunit alpha inhibitor
Gene Name (Vector)
hypoxia inducible factor 1 alpha subunit inhibitor
Gene Symbol
HIF1AN
HGNC ID
HGNC:17113
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1050
ORF Size (bp)
1050 bp
Protein Name (eCommerce)
Hypoxia-inducible factor 1-alpha inhibitor
RefSeq ID
NM_017902
RefSeq Synonyms
NM_017902, BC007719,
Research Areas
Cardiovascular,Hypoxia,Notch Signaling,Signal Transduction,Transcription Factor/Regulator
Research Areas (Faceted)
cardiovascular,cell_biology,developmental_biology,signal_transduction,transcription_translation
Species
human
Target Sentence
Factor inhibiting HIF-1 (FIH-1) hydroxylates HIF-1 alpha at 'Asp-803' in the C-terminal transactivation domain (CAD). FIH-1 functions as an oxygen sensor, and under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. FIH-1 is involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9NWT6].
UniGene ID
Hs.500788
UniProt ID (eCommerce)
Q9NWT6

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.