human HELLS Over-expression AAV

Name
AAV-h-HELLS

Cat No
AAV-210935

Availability
4-5 weeks

This is an AAV expressing Human HELLS.

AAV-210935

AAV-h-HELLS

Ready-to-use AAV expressing Human HELLS (helicase, lymphoid-specific). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ICF4; LSH; lymphoid-specific helicase; Nbla10143; PASG; proliferation-associated SNF2-like protein; SMARCA6; SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6; SWI/SNF2-related, matrix-associated, actin-dependent regulator of chromatin, subfamily A, member 6

Description (eCommerce)

HELLS, also known as LSH (lymphoid specific helicase), is a member of the SNF2 superfamily of chromatin helicases. HELLS is ubiquitously expressed and is required for the maintenance of normal DNA methylation patterns important to organism development. HELLS function has also been shown to be important to the regulation of proliferation and the expression of senescence-related genes.

Description (Vector)

HELLS encodes a lymphoid-specific helicase. Other helicases function in processes involving DNA strand separation, including replication, repair, recombination, and transcription. This protein is thought to be involved with cellular proliferation and may play a role in leukemogenesis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Gene ID

3070

Gene Name (eCommerce)

helicase, lymphoid specific

Gene Name (Vector)

helicase, lymphoid-specific

Gene Symbol

HELLS

HGNC ID

HGNC:4861

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

2514

ORF Size (bp)

2514 bp

Protein Name (eCommerce)

Lymphoid-specific helicase

RefSeq ID

NM_018063

RefSeq Synonyms

NM_018063, NM_001289075, NM_001289074, NM_001289073, NM_001289072, NM_001289071, NM_001289070, NM_001289069, NM_001289068, NM_001289067, BC146308, BC030963,

Research Areas

Aging,Apoptosis,Cell Cycle,Cell Division,Chromatin Remodeling,Helicase Activity,Immunology,Transcription Factor/Regulator

Research Areas (Faceted)

cell_biology,cell_cycle,genetics,transcription_translation,immunology

Species

human

Target Sentence

UniGene ID

Hs.655830

UniProt ID (eCommerce)

Q9NRZ9

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.