human GLUD1 Over-expression AAV

Name 
AAV-h-GLUD1
Cat No 
AAV-210018
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human GLUD1.

AAV-210018
AAV-h-GLUD1

Ready-to-use AAV expressing Human GLUD1 (glutamate dehydrogenase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
GDH; GDH1; GLUD
Description (Vector)
GLUD1 encodes glutamate dehydrogenase protein; a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid induced insulin secretion and activating mutations in this gene are a common cause of congenital hyperinsulinism. This enzyme is allosterically activated by ADP and inhibited by GTP and ATP. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Multiple pseudogenes of this gene are present in humans.
Gene ID
2746
Gene Name (Vector)
glutamate dehydrogenase 1
Gene Symbol
GLUD1
HGNC ID
HGNC:4335
ORF Size (aa)
1677
ORF Size (bp)
1677 bp
RefSeq ID
NM_005271
RefSeq Synonyms
NM_005271, NM_001318906, NM_001318905, NM_001318904, NM_001318902, NM_001318901, NM_001318900, BC112946, BC040132,
Species
human
UniGene ID
Hs.500409

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.