human GLDC Over-expression AAV

Name
AAV-h-GLDC

Cat No
AAV-209960

Availability
4-5 weeks

This is an AAV expressing Human GLDC.

AAV-209960

AAV-h-GLDC

Ready-to-use AAV expressing Human GLDC (glycine decarboxylase). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

GCE; GCSP; HYGN1

Description (Vector)

Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the P protein, which binds to glycine and enables the methylamine group from glycine to be transferred to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH).

Gene ID

2731

Gene Name (Vector)

glycine decarboxylase

Gene Symbol

GLDC

HGNC ID

HGNC:4313

ORF Size (aa)

3063

ORF Size (bp)

3063 bp

RefSeq ID

NM_000170

RefSeq Synonyms

NM_000170, BC111995, BC111993,

Species

human

UniGene ID

Hs.584238

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.