human GGCX Over-expression AAV

Name
AAV-h-GGCX

Cat No
AAV-209844

Availability
4-5 weeks

This is an AAV expressing Human GGCX.

AAV-209844

AAV-h-GGCX

Ready-to-use AAV expressing Human GGCX (gamma-glutamyl carboxylase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

VKCFD1

Description (Vector)

GGCX encodes an enzyme which catalyzes the posttranslational modification of vitamin K-dependent protein. Many of these vitamin K-dependent proteins are involved in coagulation so the function of the encoded enzyme is essential for hemostasis. Mutations in this gene are associated with vitamin K-dependent coagulation defect and PXE-like disorder with multiple coagulation factor deficiency. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene ID

2677

Gene Name (Vector)

gamma-glutamyl carboxylase

Gene Symbol

GGCX

HGNC ID

HGNC:4247

ORF Size (aa)

2277

ORF Size (bp)

2277 bp

RefSeq ID

NM_000821

RefSeq Synonyms

NM_001311312, NM_001142269, NM_000821, BC013979,

Species

human

UniGene ID

Hs.77719

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.