human GGCT Over-expression AAV

Name 
AAV-h-GGCT
Cat No 
AAV-209841
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human GGCT.

AAV-209841
AAV-h-GGCT

Ready-to-use AAV expressing Human GGCT (gamma-glutamylcyclotransferase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
C7orf24; CRF21; cytochrome c-releasing factor 21; gamma -glutamyl cyclotransferase; gamma-glutamylcyclotransferase; GCTG; GGC
Description (eCommerce)
Gamma-glutamylcyclotransferase (GGCT) catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism, and may play a critical role in glutathione homeostasis. GGCT may also play a role in cell proliferation, and the expression of GGCT is a potential marker for cancer [taken from NCBI Entrez Gene (Gene ID: 79017)].
Description (Vector)
GGCT catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism, and may play a critical role in glutathione homeostasis. The encoded protein may also play a role in cell proliferation, and the expression of this gene is a potential marker for cancer. Pseudogenes of this gene are located on the long arm of chromosome 5 and the short arm of chromosomes 2 and 20. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Gene ID
79017
Gene Name (eCommerce)
gamma-glutamylcyclotransferase
Gene Name (Vector)
gamma-glutamylcyclotransferase
Gene Symbol
GGCT
HGNC ID
HGNC:21705
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
567
Protein Name (eCommerce)
Gamma-glutamylcyclotransferase
RefSeq ID
NM_024051
RefSeq Synonyms
NM_024051, NM_001199817, NM_001199816, NM_001199815, BC019243, BC013937, BC005356, BC000625,
Research Areas
Acyltransferase,Metabolism/Metabolic Process
Research Areas (Faceted)
cell_biology,metabolism
Species
human
Target Sentence
Gamma-glutamylcyclotransferase (GGCT) catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism, and may play a critical role in glutathione homeostasis. GGCT may also play a role in cell proliferation, and the expression of GGCT is a potential marker for cancer [taken from NCBI Entrez Gene (Gene ID: 79017)].
UniGene ID
Hs.530024
UniProt ID (eCommerce)
O75223

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.