human GCLM Over-expression AAV

Name
AAV-h-GCLM

Cat No
AAV-209746

Availability
4-5 weeks

This is an AAV expressing Human GCLM.

AAV-209746

AAV-h-GCLM

Ready-to-use AAV expressing Human GCLM (glutamate-cysteine ligase modifier subunit). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

GLCLR

Description (Vector)

Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia.

Gene ID

2730

Gene Name (Vector)

glutamate-cysteine ligase modifier subunit

Gene Symbol

GCLM

HGNC ID

HGNC:4312

ORF Size (aa)

825

ORF Size (bp)

825 bp

RefSeq ID

NM_002061

RefSeq Synonyms

NM_002061, NM_001308253, BC041809,

Species

human

UniGene ID

Hs.315562

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.