human GBE1 Over-expression AAV

Name
AAV-h-GBE1

Cat No
AAV-209707

Availability
4-5 weeks

This is an AAV expressing Human GBE1.

AAV-209707

AAV-h-GBE1

Ready-to-use AAV expressing Human GBE1 (1,4-alpha-glucan branching enzyme 1). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

APBD; GBE; GSD4

Description (Vector)

GBE1 is a glycogen branching enzyme that catalyzes the transfer of alpha-1,4-linked glucosyl units from the outer end of a glycogen chain to an alpha-1,6 position on the same or a neighboring glycogen chain. Branching of the chains is essential to increase the solubility of the glycogen molecule and, consequently, in reducing the osmotic pressure within cells. Highest level of this enzyme are found in liver and muscle. Mutations in this gene are associated with glycogen storage disease IV (also known as Andersen's disease).

Gene ID

2632

Gene Name (Vector)

1,4-alpha-glucan branching enzyme 1

Gene Symbol

GBE1

HGNC ID

HGNC:4180

ORF Size (aa)

2109

ORF Size (bp)

2109 bp

RefSeq ID

NM_000158

RefSeq Synonyms

NM_000158, BC012098,

Species

human

UniGene ID

Hs.436062

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.