human GAD2 Over-expression AAV

Name 
AAV-h-GAD2
Cat No 
AAV-209539
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human GAD2.

AAV-209539
AAV-h-GAD2

Ready-to-use AAV expressing Human GAD2 (glutamate decarboxylase 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
GAD65
Description (Vector)
GAD2 encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. GAD2 may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein.
Gene ID
2572
Gene Name (Vector)
glutamate decarboxylase 2
Gene Symbol
GAD2
HGNC ID
HGNC:4093
ORF Size (aa)
1758
ORF Size (bp)
1758 bp
RefSeq ID
NM_000818
RefSeq Synonyms
NM_001134366, NM_000818, BC126329, BC126327,
Species
human
UniGene ID
Hs.231829

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.