human FADD Over-expression AAV
Category: AAV > Over-Expression
Cat. No: AAV-208257
Availability:
3-5 weeks
Name:
AAV-h-FADD
This is an AAV expressing Human FADD.
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Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- CMV (default), or choose from 30 different ubiquitous or cell specific promoter
- Reporter
- none, optional GFP, CFP, YFP, RFP or mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- FADD
- Gene Name
- Fas associated via death domain
- Gene ID
- 8772
- Gene Synonyms
- GIG3; MORT1
- ORF Size
- 627 bp
- RefSeq#
- BC000334
- Gene Description
- FADD is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.
- UniGene ID
- Hs.86131
- HGNC ID
- HGNC:3573
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