human ERCC2 Over-expression AAV
This is an AAV expressing Human ERCC2.
AAV-208057
AAV-h-ERCC2
Ready-to-use AAV expressing Human ERCC2 (ERCC excision repair 2, TFIIH core complex helicase subunit). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
basic transcription factor 2 80 kDa subunit; BTF2 p80; COFS2; CXPD; DNA excision repair protein ERCC-2; DNA repair protein complementing XP-D cells; EM9; excision repair cross-complementation group 2; TFIIH; TFIIH basal transcription factor complex 80 kDa subunit; TFIIH p80; TFIIH subunit XPD; TTD; TTD1; xeroderma pigmentosum complementary group D; XPD
Description (eCommerce)
XPD (Xeroderma pigmentosum group D-complementing protein) is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. XPD has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in the XPD gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome [taken from NCBI Entrez Gene (Gene ID: 2068)].
Description (Vector)
The nucleotide excision repair pathway is a mechanism to repair damage to DNA. The protein encoded by this gene is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. The gene product has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene ID
2068
Gene Name (eCommerce)
ERCC excision repair 2, TFIIH core complex helicase subunit
Gene Name (Vector)
ERCC excision repair 2, TFIIH core complex helicase subunit
Gene Symbol
ERCC2
HGNC ID
HGNC:3434
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2049
ORF Size (bp)
2049 bp
Protein Name (eCommerce)
TFIIH basal transcription factor complex helicase XPD subunit
RefSeq ID
NM_000400
RefSeq Synonyms
NM_001130867, NM_000400, BC110523, BC110522, BC108255,
Research Areas
Aging,Apoptosis,Cancer,Cell Cycle,Cytoskeleton,DNA Damage/Repair,Epigenetic Regulation of Gene Expression,Gene Expression,Helicase Activity,Host-Virus Interactions,Hypoxia,mRNA Processing,Neurobiology,Neurodevelopment,RNA Processing,Transcription Factor/Regulator
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,developmental_biology,genetics,infectious_disease,neurobiology,transcription_translation
Species
human
Target Sentence
XPD (Xeroderma pigmentosum group D-complementing protein) is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. XPD has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in the XPD gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome [taken from NCBI Entrez Gene (Gene ID: 2068)].
UniGene ID
Hs.487294
UniProt ID (eCommerce)
P18074
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.