human EIF4H Over-expression AAV

Name
AAV-h-EIF4H

Cat No
AAV-207797

Availability
4-5 weeks

This is an AAV expressing Human EIF4H.

AAV-207797

AAV-h-EIF4H

Ready-to-use AAV expressing Human EIF4H (eukaryotic translation initiation factor 4H). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

eIF-4H; eukaryotic translation initiation factor 4H; WBSCR1; Williams-Beuren syndrome chromosomal region 1 protein; Williams-Beuren syndrome chromosome region 1; WSCR1

Description (eCommerce)

eIF4H (eukaryotic translation initiation factor 4H) plays a role in modulating the RNA helicase activity of eIF4A for the initiation of translation. Haploinsufficiency of the EIF4H gene may be involved in the rare developmental disorder, Williams-Beuren syndrome (WBS).

Description (Vector)

EIF4H encodes one of the translation initiation factors, which functions to stimulate the initiation of protein synthesis at the level of mRNA utilization. EIF4H is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternative splicing of this gene generates 2 transcript variants.

Gene ID

7458

Gene Name (eCommerce)

eukaryotic translation initiation factor 4H

Gene Name (Vector)

eukaryotic translation initiation factor 4H

Gene Symbol

EIF4H

HGNC ID

HGNC:12741

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

687

ORF Size (bp)

687 bp

Protein Name (eCommerce)

Eukaryotic translation initiation factor 4H

RefSeq ID

NM_022170

RefSeq Synonyms

NM_031992, NM_022170, BC066928, BC021214, BC010021,

Research Areas

Gene Expression,Host-Virus Interactions,Metabolism/Metabolic Process,mRNA Binding,Neurobiology,RNA Binding,Translational Control

Research Areas (Faceted)

cell_biology,genetics,infectious_disease,metabolism,neurobiology,transcription_translation

Species

human

Target Sentence

eIF4H (eukaryotic translation initiation factor 4H) plays a role in modulating the RNA helicase activity of eIF4A for the initiation of translation. Haploinsufficiency of the EIF4H gene may be involved in the rare developmental disorder, Williams-Beuren syndrome (WBS).

UniGene ID

Hs.520943

UniProt ID (eCommerce)

Q15056

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.