human EIF3L Over-expression AAV

Name 
AAV-h-EIF3L
Cat No 
AAV-207760
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human EIF3L.

AAV-207760
AAV-h-EIF3L

Ready-to-use AAV expressing Human EIF3L (eukaryotic translation initiation factor 3 subunit L). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
eIEF associated protein HSPC021; EIF3EIP; eIF3l; EIF3S11; EIF3S6IP; eukaryotic translation initiation factor 3 subunit 6-interacting protein; eukaryotic translation initiation factor 3 subunit E-interacting protein; eukaryotic translation initiation factor 3 subunit L; HSPC021; HSPC025; MSTP005
Description (eCommerce)
Eukaryotic translation initiation factor 3 subunit L (EIF3L) is a component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9Y262].
Gene ID
51386
Gene Name (eCommerce)
eukaryotic translation initiation factor 3 subunit L
Gene Name (Vector)
eukaryotic translation initiation factor 3 subunit L
Gene Symbol
EIF3L
HGNC ID
HGNC:18138
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1695
ORF Size (bp)
1695 bp
Protein Name (eCommerce)
Eukaryotic translation initiation factor 3 subunit L
RefSeq ID
NM_016091
RefSeq Synonyms
NM_016091, NM_001242923, BC029265, BC007510, BC001101,
Research Areas
Translational Control
Research Areas (Faceted)
cell_biology,transcription_translation
Species
human
Target Sentence
Eukaryotic translation initiation factor 3 subunit L (EIF3L) is a component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9Y262].
UniGene ID
Hs.446852
UniProt ID (eCommerce)
Q9Y262

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.