human DYRK1A Over-expression AAV

dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1A; dual specificity tyrosine-phosphorylation-regulated kinase 1A; dual specificity YAK1-related kinase; DYRK; DYRK1; hMNB; HP86; MNB; mnb protein kinase homolog hp86; MNB/DYRK protein kinase; MNBH; MRD7; protein kinase minibrain homolog; serine/threonine kinase MNB; serine/threonine-specific protein kinase

Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (DYRK1A) a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. DYRK1A contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. DYRK1A may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. The DYRK1A gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome [taken from NCBI Entrez Gene (Gene ID: 5201)].

DYRK1A encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. DYRK1A is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms.

1859

dual specificity tyrosine phosphorylation regulated kinase 1A

dual specificity tyrosine phosphorylation regulated kinase 1A

DYRK1A

HGNC:3091

9606.0

2292

2292 bp

Dual specificity tyrosine-phosphorylation-regulated kinase 1A

NM_001396

NM_130438, NM_130436, NM_101395, NM_001396, BC172505, BC156309,

Cell Cycle,DNA Damage/Repair,EGFR Signaling,Hedgehog Signaling,Immunology,Kinase/Phosphatase,Neurobiology,Neurodevelopment,Signal Transduction,T-cell Receptor Signaling

cell_biology,cell_cycle,developmental_biology,genetics,transcription_translation,immunology,neurobiology,signal_transduction

human

Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (DYRK1A) a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. DYRK1A contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. DYRK1A may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. The DYRK1A gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome [taken from NCBI Entrez Gene (Gene ID: 5201)].

Hs.368240

Q13627